Genomic sequence data allows scientists to determine the similarities and differences between species. Studies of these essential differences indicate how genes create the proteins that determine an organism’s ability to function as a healthy individual.
Significant Sequences: Genomics Activities for Advanced Biology Students
Significant Sequences focuses on the importance of genomic data and how it is discovered. A series of paper modeling activities provides a visual representation of the genome sequencing process. Compare human, chimpanzee and mouse genomes, then compare differences in genomic information between human individuals. Transcribed DNA sequences in a simulated microarray show mutations from normal to cancerous tissue. Activities explore ethical issues inherent in gathering and publishing genome sequences. Group discussions highlight the implications of genetic testing and of sharing results with employers and insurance companies.
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Grade level: 10-12
Authors: Bruce Chapman, Juanita Chambers, Sandra Clifton, Carla L. Easter, Sarah C.R. Elgin, Janet Eubanks, Gabriella Farkas, Susan K. Flowers, Anna Cristina Garza, Michael Grupe, Elmer Kellmann, John McGrath, Chuck McWilliams, Victoria L. May, Valerie Mertz, Eric J. Richards, William C. Thoele, Marcia N. Vincent, Larry Wegmann
Developed with primary support from the Monsanto Fund; additional support provided by the Howard Hughes Medical Institute and the National Human Genome Research Institute through the Washington University Genome Sequencing Center.